We have used a model free diffusion MRI approach (S-index) to classify brain tissue types from the “proximity” or resemblance of their diffusion MRI signal profile at a sparse set of key b values (maximizing sensitivity to tissue microstructure) to a library of “signature” signal profiles (e.g. typical brain grey and white matter). 3D S-index maps have been generated and overlaid on a brain parcellation atlas from the Human Connectome Project showing differences among cortical brain areas.
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