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Abstract #4453

Imaging meningioma tumor microstructure: a comparison between quantitative histopathology and high-resolution diffusion tensor imaging

Jan Brabec1, Filip Szczepankiewicz2,3,4, Elisabet Englund5, Johan Bengzon6, Linda Knutsson1,7, Carl-Fredrik Westin2,3, Pia Sundgren4,8, and Markus Nilsson4
1Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, 2Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Clinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden, 5Clinical Sciences, Oncology and Pathology, Lund University, Lund, Sweden, 6Clinical Sciences, Neurosurgery, Lund University, Lund, Sweden, 7Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Lund University Bioimaging Center, Lund University, Lund, Sweden

We explore anisotropy of meningioma tumors by using structure tensor analysis of histological images and high-resolution diffusion MRI scans. We observed a good visual agreement between the structure- and diffusion-based anisotropy measures, but a more modest quantitative agreement. The results highlight the need to image microscopic rather than voxel-level fractional anisotropy in meningioma tumors.

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