Abstract #4315

Intravoxel incoherent motion analysis of the brain with second-order motion-compensated diffusion encoding

Naoki Ohno¹, Tosiaki Miyati¹, Tetsuo Ogino², Yu Ueda², Yuki Koshino^1,3, Yudai Shogan^1,3, Toshifumi Gabata⁴, and Satoshi Kobayashi¹

¹Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ²Philips Japan, Tokyo, Japan, ³Radiology Division, Kanazawa University Hospital, Kanazawa, Japan, ⁴Department of Radiology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan

In this study, we compared diffusion parameters with intravoxel incoherent motion (IVIM) analysis of the brain between second-order motion-compensated (2^nd-MC) and conventional (non-MC) diffusion encoding schemes. Perfusion-related diffusion coefficient with non-MC was strongly affected by bulk motion in the pons which has the largest motion in the brain. By contrast, the 2^nd-MC diffusion gradients compensated the bulk motion-induced signal loss and improved the fitting accuracy of biexponential model. The 2^nd-MC diffusion encoding reduces the bulk motion effect on IVIM analysis of the brain, thereby improving the measurement accuracy.

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