Abstract #3327

Free Breathing Magnetic Resonance Elastography in Patients with Idiopathic Pulmonary Fibrosis

Faisal S Fakhouri^1,2, Vincent Esguerra³, and Arunark Kolipaka^1,2

¹Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ²Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ³Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States

Interstitial lung diseases alter the mechanical properties of the lung parenchyma. Lung stiffness is a potential diagnostic marker. Standard breath hold techniques are difficult for patient with pulmonary disease. By using a free breathing Spin-Echo Dual-Density Spiral (SE-DDS) MRE sequence, a feasibility study was performed on 6 idiopathic pulmonary fibrosis (IPF) patients. It was found that the shear stiffness of IPF diseased lung is 2±0.48kPa for the right lung and 1.99±0.42kPa for the left lung which is significantly higher (P=0.0108 and P=0.0072) than healthy lungs, which has shear stiffness of 1.29±0.35kPa and 1.43±0.16kPa for right and left lungs, respectively.

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