Although susceptibility weighted imaging (SWI) has been the standard method for quantifying and evaluating cerebral microbleeds, more recently total lesion susceptibility obtained from quantitative susceptibility mapping (QSM) has been found to correlate with measures of disease burden and can provide more accurate estimates of microbleed volume. This study found that 2.5 times as many CMBs can be detected on SWI compared to QSM images, with the number of CMBs missed by QSM increasing as a function of decreasing CMB size, highlighting the importance of including SWI for a more accurate assessment of disease burden in these patients.
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