Abstract #3222

Reduced QSM values in the caudate and amygdala of first episode mania patients

Vanessa Wiggermann^1,2, Enedino Hernández-Torres³, Christian Kames^1,2, Leonardo E daSilveira^4,5, Taj Dhanoa⁵, Alexander Rauscher^1,2, and Lakshmi N Yatham^5,6

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of British Columbia, Vancouver, BC, Canada, ³Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁴Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, Porto Algre, Brazil, ⁵Mood Disorders Centre, University of British Columbia, Vancouver, BC, Canada, ⁶Psychiatry, University of British Columbia, Vancouver, BC, Canada

Bipolar I disorder is characterized by recurrent manic and depressive episodes. Both, dopamine and oxidative stress, resulting from mitochondrial dysfunction, have been implicated in BD and volumetric and metabolic changes have been reported. Nevertheless, it remains unknown whether changes result from treatment or ongoing disease, or if they are present at first episode mania. We used R₂* and quantitative susceptibility mapping (QSM) to assess differences in brain iron and myelination in a cohort of first episode mania patients compared to controls. Patients exhibited lower QSM values than controls in the caudate and amygdala, possibly linked to iron loss or hypermyelination.

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