Abstract #3059

Construction of mGluR5 receptor based in vivo atlas using simultaneously acquired [11C]ABP688 PET / MR data

Nicolas Kaulen^1,2, Claudia Régio Brambilla^1,3,4, Ravichandran Rajkumar^1,3,4, Shukti Ramkiran^1,3, Linda Orth^1,3, Hasan Sbaihat¹, Markus Lang⁵, Elena Rota Kops¹, Jürgen Scheins¹, Bernd Neumaier⁵, Johannes Ermert⁵, Hans Herzog¹, Karl-Josef Langen^1,4,6, Christoph Lerche¹, N. J. Shah^1,4,7,8, and Irene Neuner^1,3,4

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Faculty of Physics, Technical University Dortmund, Dortmund, Germany, ³Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ⁴JARA – BRAIN – Translational Medicine, Aachen, Germany, ⁵Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, ⁶Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁷Institute of Neuroscience and Medicine 11, INM-4, Forschungszentrum Jülich, Jülich, Germany, ⁸Department of Neurology, RWTH Aachen University, Aachen, Germany

This project aims to create a standard space in vivo atlas of the mGluR5 distribution in the healthy brain using structural and metabolic information from simultaneously acquired [11C]ABP688-PET / MR data. The structural MRI scans served as an anatomical reference to create a parametric MNI space atlas of mGluR5 non-displaceable binding potential. Validation of the atlas was performed and global as well as local reductions of mGluR5 availability in healthy smokers and schizophrenic smokers that are in line with the results of previous studies could be shown. Preliminary investigation of schizophrenic non-smokers showed slight, though not conclusive, reductions of mGluR5.

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