We found structural changes and tau protein accumulation within the hippocampus that can be simultaneously assessed at the subfield level in Alzheimer’s Disease. We found more separation among AD, mild cognitive impairment (MCI), and control groups when considering subfields than whole hippocampal SUVr. This study highlights the potential of our combined subfield analysis technique in disentangling pathologic derangements accompanying AD in the hippocampus and for providing more nuanced imaging-based measures for tracking and staging disease in vivo.
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