Abstract #3014

Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized 13C MRI and Gadoxetate

Shubhangi Agarwal¹, Jeremy Gordon¹, Natalie Korn¹, Robert A Bok¹, Cornelius von Morze², Daniel B Vigneron¹, John Kurhanewicz¹, and Michael Ohliger^1,3

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Biomedical Magnetic Resonance Laboratory, Washington University School of Medicine, St. Louis, MO, United States, ³Liver Center, University of California, San Francisco, San Francisco, CA, United States

Hyperpolarized (HP) ¹³C MRI is a promising technique that can assess the metabolic pathways in a variety of tumors non-invasively and in real time. In this study, we show the ability of a gadolinium-based contrast agent (gadoxetate) to selectively suppress the HP metabolic signal arising from normal hepatocytes by altering the relaxation rates of metabolites ¹³C pyruvate and ¹³C lactate in order to evaluate the metabolic profile of tumors within the liver.

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