Abstract #3000

Effects of Anaerobic Exercise in Skeletal Muscle Measured by Hyperpolarized [1-13C]Pyruvate in Humans

Jae Mo Park^1,2,3, Edward P Hackett², Crystal E Harrison², Galen D Reed⁴, Avneesh Chhabra¹, and Craig R Malloy²

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Electrical Engineering, University of Texas Dallas, Richardson, TX, United States, ⁴GE Healthcare, GE Healthcare, Dallas, TX, United States

Direct studies of lactate and pyruvate metabolism by biopsy or vascular cannulation during or after exercise is undesirable. The fraction of pyruvate that is oxidized to CO₂ vs. reduced to lactate in skeletal muscle was studied in healthy human subjects using hyperpolarized [1-¹³C]pyruvate at rest and after toe-lift exercise. There was a 2.5x fold increase in lactate production but negligible oxidation of pyruvate in the Krebs cycle. Hyperpolarization methods offer a novel approach to studying lactate and pyruvate metabolism in human skeletal muscle that is readily acceptable to subjects.

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