Abstract #2882

Five-minute GABA: Halving the scan time of GABA-edited MRS measurements

Mark Mikkelsen^1,2 and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Measurement of lower-concentration metabolites at ≤3T using edited MRS requires relatively long scan times (~10 min for a 27-mL voxel). We investigated whether scan times can be halved to ~5 min without a significant increase in group-level variance. GABA-edited MEGA-PRESS data from the Big GABA repository were analyzed by quantifying GABA+/Cr levels for complete datasets (320 averages; ~10 min) versus the first half of each (160 averages; ~5 min). There were no significant differences in group-level variance or GABA+/Cr levels. It appears that for a large, high-SNR voxel, GABA editing scan times of ~5 min are feasible.

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