Magnetization transfer (MT) imaging has been used for indirect assessment of macromolecules in biological tissues. In this study, we explore the value of the 3D UTE-Cones-MT sequence for volumetric quantification of magnetization transfer ratio (MTR) and macromolecular proton fraction（f） in menisci of healthy volunteers and patients with different degrees of OA. The primary results demonstrate that this method can detect compositional changes in meniscus and can be used to differentiate healthy subjects from patients with mild or advanced OA.
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