In BOLD-MRI studies, cuff compression was often used to establish the ischemia-reactive hyperemia model of calf muscle.We found some BOLD signals did not decrease during ischemia, but increased or stay the same.This study was to find the reasons why BOLD signal showed multiple trends in ischemic period and to optimize the ischemia model. BOLD scan was performed on volunteers under two cuff pressures.BOLD signals of all muscles showed a downward trend in the P1 model of partly reduced blood supply. However, in P2 model of blood supply blocked completely, BOLD signals had mostly gone up during ischemia ,unexpectedly.
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