Abstract #2293

Quantitative Assessment of Lung Compliance using both Hyperpolarized 129Xe MRI and Micro-CT

Hongchuang Li¹, Ming Zhang¹, Haidong Li¹, Xiuchao Zhao¹, Qiuchen Rao¹, Xiaoling Liu¹, Yeqing Han¹, Xianping Sun¹, Xinrui Wang², Chaohui Ye¹, Xin Lou², and Xin Zhou¹

¹Wuhan Institute of Physics and Mathematics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, ²Department of Radiology, Chinese PLA General Hospital, Beijing, P. R. China, Beijing, China

Lung compliance is commonly used in clinical diagnosis of pulmonary fibrosis and emphysema, and it is generally measured using pulmonary function tests (PFTs) in clinic. In this study, the imaging methods including both hyperpolarized ¹²⁹Xe MRI and micro-CT were used to quantify lung compliance in rats, and the significant correlation was found between these two imaging methods. Our study also demonstrates the feasibility of measuring lung compliance using hyperpolarized ¹²⁹Xe MRI, which would contribute to fully understanding the lung function changes caused by the pulmonary diseases.

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