Abstract #2269

4D flow MRI vs. Doppler Echocardiography: Data Integration Framework for Direct Comparison of Intra-cardiac Flow Dynamics

Jeesoo Lee^1,2, Nadia El Hangouche², Alex J Barker³, James D Thomas², and Michael Markl^1,4

¹Radiology, Northwestern University, Chicago, IL, United States, ²Cardiology, Northwestern Memorial Hospital, Chicago, IL, United States, ³Radiology, University of Colorado Denver, Denver, CO, United States, ⁴Biomedical Engineering, Northwestern University, Chicago, IL, United States

We developed a framework to integrate 4D flow MRI with color Doppler echocardiography (CDE) for direct localized inter-modal velocity comparison. The framework combines CDE and 4D flow MRI data by using cine-MRI and a two-step image registration; 1) registration of CDE to cine-MRI and 2) registration of cine-MRI to 4D flow MRI. As a result, a voxel-wise inter-modal velocity difference map overlaid to a tissue image was constructed. Six healthy subjects with a same-day CDE and 4D flow MRI were utilized and a strong correlation with moderate agreement was found in the LVOT.

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