Abstract #2126

Black-blood 3D DCE-MRI of the aortic wall with AIF-free pharmacokinetic modeling: feasibility in abdominal aortic aneurysm patients

Jasper Schoormans¹, Claudia Calcagno², Reza Indrakusuma³, Hamid Jalalzadeh³, Ron Balm³, Stefan Smorenburg⁴, Gustav J Strijkers¹, Aart J Nederveen⁵, and Bram F Coolen¹

¹Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ²The BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Vascular Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands

We introduced 3D black-blood DCE MRI in combination with AIF-free modeling to facilitate the measurement of pharmacokinetic parameters in the aorta vessel wall of patients with an abdominal aortic aneurysm. Our method enables 3D assessment of microvascularization and permeability which could assist a clinical risk assessment of this condition.

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