Abstract #2097

Fourier Transform based Velocity-Selective Labeling Pulses for Myocardial ASL

Vanessa Landes¹, Ahsan Javed², Terrence Jao³, Qin Qin^4,5, and Krishna Nayak²

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ³Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴Radiology, Johns Hopkins University, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We present an improved velocity-selective (VS) labeling pulse for myocardial arterial spin labeling (ASL) that addresses limitations of prior pulses. The proposed pulse is designed using a Fourier Transform based Velocity-Selective (FT-VS) pulse train and optimized to label coronary blood while not labeling myocardium. Myocardial VSASL experiments were performed in healthy adult volunteers. The proposed pulse provided comparable measurements to FAIR ASL and a 2.5-fold reduction in physiological noise compared to a prior VS-ASL pulse.

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