Abstract #2089

Flow Effects on MOLLI T1 Mapping

Zhengyang Ming^1,2, Hengjie Liu^1,2, Caroline Colbert^1,2, Kim-Lien Nguyen^1,2,3, and Peng Hu^1,2

¹Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine Inter-Departmental Graduate Program, University of California, Los Angeles, Los Angeles, CA, United States, ³Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

T1 relaxation time for myocardial tissue represents a biomarker for a variety of pathologies. High resolution and pixel-wise T1 mapping can be acquired with Modified Look-Locker Imaging1 (MOLLI). Besides, T1 measurements of blood can be used as a reference value to calculate function parameters like extracellular volume (ECV) fraction2,3 and myocardial blood volume4.5 (MBV). Blood flow may affect blood T1 measurements and cause further deviation in calculating function parameters 6. In our work, we proposed a MOLLI-based flow model to simulate flow effect. Substantial T1 deviation may happen when the spin replacement rate is between 0.65 and 0.70.

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