Abstract #1932

White Matter Microstructural Changes in an Absence Epilepsy Mouse Model

Gustavo Chau Loo Kung¹, Juliet Knowles², Erpeng Dai³, John Huguenard², Michelle Monje², and Jennifer McNab³

¹Bioengineering Department, Stanford University, Stanford, CA, United States, ²Neurology Department, Stanford University, Stanford, CA, United States, ³Radiology Department, Stanford University, Stanford, CA, United States

A previously unexplored possibility is that maladaptive myelination may contribute to both the predisposition to seizures and cognitive impairment in diseases such as absence epilepsy. This work presents MRI white matter microstructural measurements in ex vivo mouse brains from the Scn8amed+/- model of absence epilepsy. We obtained estimates of fractional anisotropy, myelin volume fraction and g-ratio. Our results are suggestive of thicker myelin sheaths, which is consistent with g-ratio data obtained by electron microscopy. We look to expand the current analysis to perform longitudinal measurements of the evolution of this particular type of epilepsy and its interplay with aberrant myelination.

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