Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a sin- gle intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.
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