Abstract #1796

Higher b-value diffusion improves correlation with cortical myelin content

Sandy Mournet^1,2, Gosuke Okubo^1,2,3, Ismail Koubiyr^1,2, Valentin H Prevost⁴, Clémence Bal², Bei Zhang⁵, Hiroshi Kusahara ⁴, Nobuyasu Ichinose⁴, Bruno Triaire⁴, Bassem Hiba⁶, Vincent Dousset^1,2,7, and Thomas Tourdias^1,2,7

¹Neurocentre Magendie, INSERM U1215, Bordeaux, France, ²Université de Bordeaux, Bordeaux, France, ³Department of Radiology, Tenri Hospital, Nara, Japan, ⁴Canon Medical Systems Corporation, Otawara, Japan, ⁵Canon Medical systems Europe, Paris, France, ⁶Centre de neuroscience cognitive, CNRS UMR 5229, Université Claude Bernard Lyon, Lyon, France, ⁷Neuroimagerie diagnostique et thérapeutique, CHU de Bordeaux, Bordeaux, France

In diffusion MRI, the use of very high b-value remains very challenging. In this study, we scanned 9 volunteers with a protocol of dMRI sequences using b values from 1000 to 5000 s/mm². We compared cortical surface map of myelin (T1wi/T2wi) to maps of mean diffusivity (MD) computed from each b value. As opposed to b1000 s/mm², MD maps from b3000 and b5000 inversely mirrored the myelin maps. With increasing b-values, multiple regression models confirmed an increasing negative association between myelin and MD. The MD obtained with high b-value is sensitive to subtle cellular variations such as the cortical myeloarchitecture.

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