Abstract #1618

Angiogenesis following peripheral blood stem cell therapy: evidence from perfusion MRI of patients with ischemic stroke

Chao-Chun Lin¹, Wen-Chau Wu², Woei-Cherng Shyu³, Yi-Jui Liu⁴, Hing-Chiu Chang⁵, Yu-Chien Luo³, Der-Cherng Chen³, Chia-Wei Lin³, Hsiao-Wen Chung⁶, and Shinn-Zong Lin⁷

¹Department of Radiology, China Medical University Hospital, Taichung, Taiwan, ²Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan, ³China Medical University Hospital, Taichung, Taiwan, ⁴Department of Automatic Control Engineering, Feng-Chia University, Taichung, Taiwan, ⁵Department of Diagnostic Radiology, University of Hong Kong, Hong Kong, Hong Kong, ⁶Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ⁷Buddhist Tzu Chi General Hospital, Hualien, Taiwan

Dynamic susceptibility-contrast perfusion-weighted MRI was performed on 15 chronic stroke patients receiving intracerebral implantation of peripheral blood stem cells (PBSC) at baseline and 6 longitudinal stages after therapy to derive relative cerebral blood volume around the implanted graft relative to contralateral white matter (rCBV ratio), with 15 control patients receiving baseline MRI plus two follow-ups. Nine of the 15 patients (60%) in the PBSC group showed significantly increased rCBV ratio than the baselines (1.39±0.60 versus 1.07±0.44; p < 0.01) at one week after implantation only, preceding functional improvements starting at one month as assessed by NIH stroke scale.

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