The present psychoradiological study demonstrated
significant alterations both in global and nodal topological properties of
single-subject brain morphological networks in a relatively large population of
patients with ALS relative to HCs. This was achieved by combining graph
theoretical analysis with a method of describing patterns of intercortical morphological
similarities in individual participants using structural MRI data. We found
that ALS showed a weaker small world organized brain network in global
properties and decreased nodal centralities mainly in prefrontal-limbic network
relative to HCs. Further, the nodal efficiency of right inferior frontal
gyrus was positively correlated to ALSFRS
in ALS group.
This abstract and the presentation materials are available to members only; a login is required.