Abstract #1569

Serial assessment of magnetic susceptibility in the primary motor cortex in limb-onset Amyotrophic Lateral Sclerosis

Anjan Bhattarai^1,2, Zhaolin Chen², Phillip G. D. Ward², Paul Talman³, Susan Mathers⁴, Thanh Phan⁵, Caron Chapman⁴, James Howe⁴, Sarah Lee⁴, Yennie Lie⁴, Gary F Egan², and Phyllis Chua^1,4

¹Department of Psychiatry, Monash University, Clayton, Australia, ²Monash Biomedical Imaging, Monash University, Clayton, Australia, ³Department of Neuroscience, Barwon Health, Geelong, Australia, ⁴Statewide Progressive Neurological Services, Calvary Health Care Bethlehem, South Caulfield, Australia, ⁵Department of Neuroscience, Monash Health, Clayton, Australia

We performed in-vivo measurements of the magnetic susceptibility in the motor cortex in individuals with Amyotrophic Lateral Sclerosis (ALS) at baseline and six-month follow-up, and healthy controls at baseline using Quantitative Susceptibility Mapping (QSM). The results show significant susceptibility difference between individuals with ALS compared to healthy controls. There was a trend towards more pronounced susceptibility changes in lumbar onset compared to healthy controls than cervical onset ALS compared to healthy controls. These findings may lead to the development of a sensitive neuroimaging biomarker that can provide meaningful insights into pathophysiologic changes in ALS subtypes.

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