Abstract #1501

Exploration of structural brain volume changes in patients with early- and middle-late-onset Parkinson's disease using the MPRAGE sequence

Ruichen Zhao¹, Chunyan Zhang¹, Jinxia Zhu², Bénédicte Maréchal³, Chen Chen¹, Hong Lu⁴, and Jingliang Cheng¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG；Department of Radiology, Lausanne University Hospital and University of Lausanne；LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

In this study, the structural brain volume changes in early-onset (EOPD) and middle-late-onset Parkinson’s disease (M-LOPD) patients were evaluated. We found different patterns of volume changes in these patients. The results showed that some brain regions might represent a potential imaging marker for the early diagnosis of EOPD and could explain different clinical characteristics. MPRAGE-based morphometry may be a suitable method to provide a reference for EOPD diagnoses in clinical practice.

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