Abstract #1397

Gray matter relaxation rates show different correlation patterns for cognitive impairment and physical disability in Multiple Sclerosis.

Maria Teresa Cassiano¹, Roberta Lanzillo², Bruno Alfano³, Teresa Costabile², Marco Comerci³, Anna Prinster³, Marcello Moccia², Rosario Megna³, Vincenzo Brescia Morra², Arturo Brunetti¹, and Mario Quarantelli³

¹Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy, ²Department of Neurosciences, Reproductive Science and Odontostomatology, University "Federico II", Naples, Italy, ³Biostructure and Bioimaging Institute, National Research Council, Naples, Italy

To assess voxelwise in gray matter the correlation between relaxation rates and both physical and cognitive impairment in MS, R1 and R2 relaxation rate maps from 241 Relapsing-Remitting MS patients were assessed voxelwise for correlation with EDSS and the percentage of impaired cognitive test.

Inverse correlation between EDSS and R2 were detected throughout the brain, while inverse correlations with R1 were mostly limited to perirolandic and supramarginal cortices.

Cognitive impairment correlated negatively with R1, and to a lesser extent with R2, in the limbic system and dorsolateral prefrontal cortices.

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