Abstract #1396

Diffusion tractography evaluation of specificity of PASAT and SDMT to cognitive pathway in multiple sclerosis

Pallab K Bhattacharyya^1,2, Robert Fox³, Jian Lin¹, Hong Li⁴, Ken Sakaie¹, and Mark Lowe¹

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ²Radiology, Cleveland Clinic Lerner College of Medicine, CLEVELAND, OH, United States, ³Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States

Paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT) are two most commonly used tests to evaluate cognitive performance in MS. The specificity of the two tests to cognitive network in brain was evaluated with diffusion tensor imaging and correlating transverse diffusivity (TD) along different functionally relevant pathways with PASAT/SDMT scores. While SDMT showed association with TD along all pathways (and whole brain white matter), PASAT was associated with only frontoparietal pathway, establishing its specificity to cognitive network.

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