Abstract #1371

Decoupling of brain activity from connectome in multiple sclerosis and neuromyelitis optica

Chenfei Ye¹, Jing Huang², Haiyan Lv³, Jie Lu², and Ting Ma^1,4,5,6

¹Department of Electronic and Information Engineering, Harbin Institute of Technology at Shenzhen, Shenzhen, China, ²Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China, ³Shenzhen MindsGo Life Technology Co.Ltd, Shenzhen, China, ⁴Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, ⁵Peng Cheng Laboratory, Shenzhen, China, ⁶National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China

Coupling of brain functional activity with brain structural network (connectome) plays a key role in cognition and movement. In this study, we anticipated that the structural-functional coupling would be altered in multiple sclerosis (MS) and neuromyelitis optica (NMO). By introducing the graph frequency analysis on diffusion and functional MR images, we found that brain activity in patient with both MS and NMO deviated from the underlying structural network, indicating disrupted structural-functional coupling caused by neuronal inflammation and demyelination.

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