Spinal cord involvement is an important feature of antibody-mediated demyelination, as in AQP4-Ab-positive NMOSD and MOGAD, as well as in MS. In this study of 80 participants (20 MOGAD, 20 AQP4-Ab, 20 MS, 20 health volunteers) we use multimodal cervical cord MRI to show that MOGAD may predominantly affect the grey matter; AQP4-Ab disease shows the most severely affected cord, localised to lesional areas; and that MRI metrics in the cervical cord do not differentiate these three conditions but have clinical relevance in their association with disability and pain scores, independent of disease type.
This abstract and the presentation materials are available to members only; a login is required.