The impact of simultaneous multi-slice imaging (SMS) with short repetition time (TR) accelerated acquisition on diffusion tensor imaging (DTI) combined with readout-segmented echo planar imaging (RESOLVE) on the intra-cranial nerves is unexplored. Compared to non-SMS RESOLVE-DTI, two SMS RESOLVE-DTI protocols showed higher pontine signal-to-noise ratio (SNR). Consistent measures of different DTI metrics of cisternal trigeminal nerves across the three RESOLVE-DTI protocols and significant positive correlations of mean DTI metrics in pairwise comparison across these suggest that SMS RESOLVE-DTI allows fast and reliable evaluation of the microstructural integrity of the cisternal trigeminal nerve, with possible utility in trigeminal neuralgia.
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