Abstract #1084

B1 Inhomogeneity at 3T causes spatially non-reproducible and inaccurate cardiac creatine CEST-contrast in healthy controls

Wissam AlGhuraibawi¹, Kevin Godines¹, Mark Velasquez¹, Sinyeob Ahn², Wolfgang Rehwald³, and Moriel Vandsburger¹

¹Bioengineering, University of California Berkeley, Berkeley, CA, United States, ²Siemens Healthineers, Concord, CA, United States, ³Siemens Healthineers, Durham, NC, United States

CEST-MRI is an emerging molecular imaging method for non-invasive assessment of cardiomyocyte metabolites. In cardiac CEST-MRI, spatial B₁ inhomogeneity across the myocardium significantly reduces the accuracy of measured CEST contrasts. Deviation from the prescribed B₁ leads to altered creatine CEST contrast due to both reduced labeling efficiency and heightened magnetization transfer and direct water direct saturation across the heart. The final impact is measurement of falsely and substantially reduced creatine CEST contrast in the healthy heart.

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