White matter hyperintensities interfere with the course of white matter tracts, and disrupt connections between gray matter regions. This process might potentially underlie cognitive decline. In the large population-based Maastricht Study (n=5083), we found an association of lower processing speed scores with larger white matter hyperintensities and smaller total tract volumes in important processing speed related white matter tracts. These findings provide more insight into how white matter hyperintensities seem to influence the cognition-sensitive organization of white matter tracts.
This abstract and the presentation materials are available to members only; a login is required.