Abstract #0910

Modelling the temporal cascade of abnormalities in diffusion magnetic resonance imaging in sporadic Creutzfeldt-Jakob disease

Riccardo Pascuzzo¹, Vikram Venkatraghavan², Marco Moscatelli¹, Marina Grisoli¹, Esther E. Bron², Stefan Klein², Janis Blevins³, Gianmarco Castelli¹, Lawrence B. Schonberger⁴, Pierluigi Gambetti⁵, Brian S. Appleby³, and Alberto Bizzi¹

¹Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, ²Biomedical Imaging Group Rotterdam, Departments of Medical Informatics & Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ³National Prion Disease Pathology Surveillance Center, Case Western Reserve University, School of Medicine, Cleveland, OH, United States, ⁴National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States, ⁵Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States

The subtypes of sporadic Creutzfeldt-Jakob disease (sCJD), determined only at autopsy, may have different abnormality patterns in diffusion-weighted magnetic resonance imaging (DW-MRI) according to few reports. For the first time, we provide temporal cascades of the DW-MRI abnormalities in seven distinct sCJD subtypes using a data-driven technique named “discriminative event-based model”. Based on these cascades, we propose a novel procedure to identify the subtype of a patient. We found that sCJD subtypes have either initial cortical (MM/MV1, MM/MV2C, VV1 subtypes) or subcortical involvement (MV2K and VV2) with specific orderings of DW-MRI abnormalities, allowing a correct subtype prediction in most cases.

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