Perivascular space (PVS) is a pial-lined, fluid-filled structure that surrounds vessels in the cerebral cortex 1,2, and occupies a large portion of the cerebral tissue. The contribution of PVS fluid diffusion signal is less known and could be challenging distinguish from perfusion-related signal changes (or IVIM); because both are expected to affect diffusion at low b-values. Here we showed that PVS fluid significantly contributes to diffusion signal at low b-values dominating tissue or perfusion-related signal changes.
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