Abstract #0698

Is [1-13C]Lactate Converted to 13C-Bicarbonate in the Human Brain?

Casey Y Lee^1,2, Hany Soliman³, Nadia D Bragagnolo^1,2, Albert P Chen⁴, William J Perks⁵, Chris Heyn⁶, Sandra E Black⁷, and Charles H Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴GE Healthcare Technologies, Toronto, ON, Canada, ⁵Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Department of Medicine (Neurology) and Hurvitz Brain Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Hyperpolarized [1-¹³C]lactate and ¹³C-bicarbonate images were acquired with and without spectral-spatial lactate saturation in the brains of control participants. A previously published atlas-based analysis was used to convert [1-¹³C]lactate and ¹³C-bicarbonate signals into z-scores to quantify the effect of [1-¹³C]lactate saturation. The analysis showed that lactate z-scores were changed in the saturation regions, as expected. The saturation of [1-¹³C]lactate signals did not significantly affect ¹³C-bicarbonate signals.

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