Abstract #0576

Probing ballistic flow in the placenta using flow-compensated and non-compensated diffusion MRI

Ling Jiang^1,2, Taotao Sun^1,2, Yuhao Liao³, Yi Sun⁴, Yi Zhang³, Zhaoxia Qian^1,2, and Dan Wu³

¹Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ²Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China, ³Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ⁴MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Intravoxel incoherent motion (IVIM) imaging is frequently used to evaluate microcirculatory flow. With the conventional diffusion MRI, IVIM effects include both pseudo-diffusive microcirculatory flow and bulk (or ballistic) blood flow. We propose a joint use of flow-compensated (FC) and non-FC diffusion gradient waveforms to specifically probe the fraction and velocity of ballistic flow in the placenta. The measured ballistic flow velocity showed a high correlation with umbilical flow based on Doppler ultrasound and a negative correlation with gestational age. These results demonstrated the potential of using FC/NC dMRI to noninvasively measure flow velocity inside the placenta.

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