Abstract #0529

Variable Flip Angle 3D Echo Planar Time-Resolved Imaging (vFA 3D-EPTI) for Fast Multi-Compartment Quantitative Mapping

Zijing Dong^1,2, Fuyixue Wang^1,3, Kwok-Shing Chan⁴, Timothy G. Reese¹, Berkin Bilgic¹, José P. Marques⁴, and Kawin Setsompop^1,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ⁴Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands

Multi-compartment models have been developed to detect the microstructure properties of brain tissue using multi-modal MRI, but are limited by the long scan time of multi-contrast multi-parametric acquisition. In this work, a novel variable flip angle EPTI (vFA 3D-EPTI) technique is developed to quickly acquire rich multi-contrast information for multi-compartment analysis. The optimized ‘temporal variant CAIPI’ sampling was used, and an augmented subspace reconstruction with multi-compartment modelling is also developed to accurately reconstruct complex signal evolution. Through this approach, myelin water fraction, proton density, multi-compartment T₁, T₂^* maps can be acquired simultaneously in 12 minutes at 1-mm isotropic resolution.

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