Abstract #0508

Towards clinical CEST-MRF: whole brain snapshot CEST MR Fingerprinting at 3T using spin-lock saturation and a centric 3D-EPI readout

Kai Herz¹, Sebastian Mueller¹, Or Perlman², Ruediger Stirnberg³, Tony Stoecker^3,4, Klaus Scheffler^1,5, Christian Farrar², and Moritz Zaiss^1,6

¹Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ³German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ⁴Department of Physics and Astronomy, University of Bonn, Bonn, Germany, ⁵Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, Tuebingen, Germany, ⁶Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

Quantitative CEST imaging is still not applied in clinical routine, as both quantification and whole brain coverage require usually long scan times. In this work, we present a CEST-MRF protocol using spin-lock saturation pulses and a fast 3D-EPI readout with whole brain coverage. This enables a fast generation of quantitative amide proton concentration maps of the entire brain at a clinical scanner.

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