Abstract #0507

Tailored spectral-spatial saturation pulses for spatially uniform saturation in CEST imaging

Huiwen Luo¹, Wissam AlGhuraibawi², Kevin Godines², Daniel Gochberg³, Moriel Vandsburger², and William A Grissom¹

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A tailored spectral-spatial saturation pulse was developed to produce a flat flip angle profile across the heart and achieve more uniform CEST saturation despite B₁ inhomogeneity at 3 Tesla. The tailored saturation pulse train was simulated for a two-pool system to evaluate the z-spectrum at each spatial location in the heart, based on an in vivo 3 Tesla B₁ map. Whereas CEST saturation generated with a conventional Gaussian pulse yielded CEST contrast of 2.60±1.59% across the ventricle, the tailored pulse produced more uniform saturation across the heart which resulted in both greater and more uniform CEST contrast of 4.64±0.34%.

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