Histopathological examination is the current gold standard for evaluating tumor response to anti-cancer therapy; though it is possible only after surgery. Non-invasive imaging biomarkers of tumor response to therapy may be useful in optimizing existing treatments improving overall outcome. The spin-lattice relaxation time of water protons (T1) reflects therapeutic changes in tumor and is thus a generic marker of tumor response to therapy. Experimental results showed T1 relaxation time reduces upon successful chemotherapy and thus, a change in tumor T1 may be a non-invasive imaging marker of chemo-sensitivity and chemotherapy response.
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