Abstract #0259

Evaluating the Relationship Between Dynamic [18F]-Sodium Fluoride Uptake Parameters and MRI Knee Osteoarthritic Findings

Lauren Watkins¹, James MacKay^2,3, Bryan Haddock⁴, Valentina Mazzoli⁵, Scott Uhlrich⁶, Garry Gold⁵, and Feliks Kogan⁵

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Radiology, University of East Anglia, Norwich, United Kingdom, ³Radiology, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, København, Denmark, ⁵Radiology, Stanford University, Stanford, CA, United States, ⁶Mechanical Engineering, Stanford University, Stanford, CA, United States

Abnormal bone physiology is a potential mechanism for the progression of knee osteoarthritis. Molecular information derived from PET imaging has shown promise in early detection of bone metabolic abnormalities. Here we investigated kinetic parameters of PET tracer ([¹⁸F]-NaF) uptake in subjects with knee osteoarthritis and evaluated the relationship between kinetic tracer uptake parameters and structural MRI findings. The kinetic parameters for [¹⁸F]-NaF delivery and uptake to regions of bone containing osteophytes, bone marrow lesions, and adjacent to cartilage lesions identified on MRI were significantly different compared to normal-appearing bone, suggesting strong spatial relationships between structural damage and bone metabolic abnormalities.

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