Osteoarthritis (OA) is a joint disorder, consisting of cartilage degeneration and metabolic bone changes, which have previously been correlated by using [18F]-NaF PET/MRI in the knee. However, these correlations were derived using averaging methods in areas of [18F] uptake in the bone and surrounding cartilage T1ρ/T2 mean values, which could miss potential multifaceted mechanisms that are not spatially correlated in the joint. The goal of this study is to find complex patterns in OA by building a cartilage-bone interface and using principal component analysis to find cartilage-bone interactions and find associations with known manifestations of OA.
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