In the BECOME trial, subjects experienced progressively increased T1W signal changes in deep grey matter nuclei. This retrospective analysis concluded these signal changes also can be seen in the diploic space bone marrow. While increasing trends in hypophosphatemia and leukopenia were also seen in the original study, this analysis has shown that these metabolic abnormalities are not associated with increased marrow signal and that low phosphate and low WBC were not associated with one another. This rejects our hypothesis that gadolinium deposition might interact with a common osteoclast-WBC progenitor cell to result in the metabolic abnormalities.
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