Abstract #0175

Multi-T1D weighting ihMT imaging in the Cuprizone mouse model

Andreea Hertanu¹, Lucas Soustelle¹, Arnaud Le Troter¹, Julie Buron^1,2, Victor Carvalho^1,3, Myriam Cayre², Pascale Durbec², Gopal Varma⁴, David C. Alsop⁴, Olivier M. Girard¹, and Guillaume Duhamel¹

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²Aix-Marseille Univ, CNRS, IBDM, Marseille, France, ³Aix-Marseille Univ, CNRS, ICR, Marseille, France, ⁴Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) is a myelin sensitive MRI technique that provides access to multiple contrast regimes by tuning the amount of dipolar relaxation time (T_1D) weighting of the sequence. This opens new perspectives to characterize the sensitivity and specificity of ihMT for myelin in a pathological context. In this study, multiple T_1D-weighting ihMT imaging was investigated in the cuprizone mouse model. IhMT signals compared to myelin imaging with fluorescence microscopy demonstrate that ihMT techniques that are weighted towards long T_1D values are more specifically related to myelin content during the demyelinating/remyelinating phases of the cuprizone model.

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