In this study, a recently proposed MRI blood oximetry technique was optimized to improve the accuracy of oxygen saturation measurements. Simulations of the Luz-Meiboom model were performed to optimize the T2-prep refocusing intervals and to guide the selection of the blood pool used for nuisance parameter estimation. Blood oxygen saturation measurements were validated against MR-guided cardiac catheterization under the same anesthetic conditions in patients with congenital heart disease, with the proposed O2 mapping technique demonstrating improved agreement with blood gas analysis. The proposed improvements may allow for future examination of blood pool oxygenation without the need for invasive cardiac catheterization.
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