Abstract #0091

Time-dependent Diffusion MRI of Pediatric Brain tumor at 3T

Hongxi Zhang¹, Hua Li², Zhipeng Shen¹, Yi Zhang³, and Dan Wu³

¹Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Nemours AI duPont Hospital for Children, Wilmington, DE, United States, ³Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Diffusion-time dependent diffusion MRI has shown potential in probing tumor microstructure. This study investigated the feasibility of time-dependent dMRI to map brain tumor microstructure in a pediatric population at 3T. Oscillating and pulsed gradient dMRI was performed to access a series of diffusion times and b-values, and the data were fitted with the IMPULSED model to estimate cell diameter, intracellular fraction, and diffusivity metrics. In a pilot study of 17 pediatric brain tumor patients, all high-grade tumors showed higher intracellular fraction and cellularity than the low-grade ones, while the cell diameter showed differentiation among different types of high-grade tumors.

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