Abstract #0018

Exploring label dynamics of velocity selective arterial spin labeling in the kidney

Isabell K. Bones¹, Suzanne L. Franklin^1,2, Anita A. Harteveld¹, Matthias J.P. van Osch², Sophie Schmid², Jeroen Hendrikse³, Chrit Moonen¹, Marijn van Stralen¹, and Clemens Bos¹

¹Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ²C.J.Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

VSASL for renal application has constraints on the cut-off velocity, as low V_c in the presence of respiratory motion causes spurious labeling of moving tissue. With higher V_c, label could be generated more upstream in the vascular tree, potentially introducing ATT sensitivity. To study label dynamics of renal VSASL using a V_c compatible with free-breathing (V_c of 10cm/s), data at multiple time points were acquired. High ASL signal was already observed at early time points, thus supporting that spatially non-selective VSASL in the kidney generates label close to, or even inside the target tissue, also using a free-breathing compatible V_c.

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