Abstract #0017

Differences in quantitative glioma perfusion imaging with ASL and DSC: validation with 15O-H2O PET

Jan Petr¹, Niels Verburg², Joost P.A. Kuijer³, Thomas Koopman³, Vera C. Keil⁴, Esther A.H. Warnert⁵, Frederik Barkhof^3,6, Jörg van den Hoff¹, Ronald Boellaard³, Philip C. de Witt Hamer², and Henri J.M.M. Mutsaerts^3,7

¹Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Neurosurgical Center Amsterdam, Amsterdam University Medical Center, location VU, Amsterdam, Netherlands, ³Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VU, Amsterdam, Netherlands, ⁴Department of Neuroradiology, Bonn University Hospital, Bonn, Germany, ⁵Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, ⁶UCL Institutes of Neurology and Healthcare Engineering, London, United Kingdom, ⁷Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium

While agreement between ASL, DSC, and PET perfusion is well established in healthy volunteers, an analogous comparison in gliomas is still missing and more challenging. We compared ASL and DSC perfusion measurements with the gold-standard of ¹⁵O-H₂O-PET perfusion measurements in eight patients diagnosed with gliomas. We showed the importance of normalization to the contralateral hemisphere, and identified several examples of different regional perfusion as assessed with ASL and DSC and interpreted them using the PET reference.

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