Abstract #5013

Improved tumor characterization with direct saturation corrected (DISC) amide proton transfer (APT) MRI in glioma patients

Yin Wu¹, Yinsheng Chen², Jie Liu¹, Cong Li², Xiaofei Lv³, Zhongping Chen², Phillip Zhe Sun^4,5, and Hairong Zheng¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China, ³Department of Medical Imaging, Cancer Center, Sun Yat-Sen University, Guangzhou, China, ⁴Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ⁵Department of Radiology, Emory University School of Medicine, Atlanta, GA, United States

Recently, a direct saturation correction (DISC) method has proved to improve APT quantification in pulsed-RF CEST imaging. In this study, performance of tumor characterization was compared among routine asymmetry analysis (MTR_asym), three-point offset (APT_3pts) and the DISC methods in glioma patients at 3T. Although all methods revealed significant APT elevation in tumor region compared to that in the contralateral normal appearing white matter, the DISC method exhibited substantially higher contrast-to-noise ratio (2.16±0.90) between the two regions than that of MTR_asym (1.78±1.08) and APT_3pts (0.87±0.57), demonstrating its superiority in improved sensitivity for tumor characterization.

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