Abstract #5012

Phosphocreatine CEST (PCrCEST) Detects Phosphocreatine and pH Changes in the Muscle at 15.2T

Julius Juhyun Chung^1,2, Tao Jin³, Jung Hee Lee^1,2,4,5, and Seong-Gi Kim^1,2,4

¹Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Samsung Advanced Insitute for Health Sciences and Technology, SKKU, Seoul, Korea, Republic of, ³Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ⁵Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

Phosphocreatine plays a major role in the metabolic upkeep of tissues such as the muscles and the heart. Chemical Exchange-sensitive MRI has been shown to have sensitivity to phosphocreatine. We examine the sensitivity of Phosphocreatine CEST (PCrCEST) to changes in phosphocreatine levels and pH via PCrCEST imaging in the mouse hindlimb while inducing euthanasia and present high resolution PCrCEST maps in the ante- and post-mortem.

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